H-9 dihydrochloride( —— )

Catalog No. M33864 CAS No. 116700-36-8

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Product Name

H-9 dihydrochloride
Note

Research use only, not for human use.
Brief Description

H-9 dihydrochloride is a potent protein kinase (PKA) inhibitor.H-9 Dihydrochloride significantly reduces the excitatory response to 5-HT at low concentrations.
Description

H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines.
In Vitro

H-9 Dihydrochloride significantly inhibits A431 cells.H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases.
In Vivo

H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration.
Synonyms

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Pathway

Apoptosis
Target

PKA
Recptor

PKA | EGFR | 5-HT Receptor
Research Area

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Indication

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1. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6. ?

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